비글견 경골에서 임플란트 식립 시 혈소판 농축 혈장이 골형성에 미치는 영향

국민석; 정승곤; 심경미; 강성수; 박홍주; 유선열; 오희균

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비글견 경골에서 임플란트 식립 시 혈소판 농축 혈장이 골형성에 미치는 영향
The effect of platelet rich plasma in bone formation on implant installation in the tibia of beagle dogs

대한구강악안면외과학회지 2010년 36권 2호 p.71 ~ 77

국민석, 정승곤, 심경미, 강성수, 박홍주, 유선열, 오희균,

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국민석 ( Kook Min-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
정승곤 ( Jung Seung-Gon ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
심경미 ( Shim Kyung-Mi ) - 남부대학교 방사선학과
강성수 ( Kang Sung-Soo ) - 전남대학교 수의과대학
박홍주 ( Park Hong-Ju ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
유선열 ( Ryu Sun-Youl ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
오희균 ( Oh Hee-Kyun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실

KMID : 0355620100360020071

Abstract

Introduction: The purpose of this study is to evaluate the effect of platelet rich plasma in bone formation and osseointegration of implant installed in the bone marrow space.

Materials and Methods: Five beagle dogs were used as experimental animals. Two implants were installed on each tibia in the dogs. Implants of the control group were installed with no additional graft. Those of the experimental group 1 were installed with autogenous bone graft from the ilium autogenous bone. Platelet rich plasma (PRP) alone was used in experimental group 2 and the mixture of PRP and autogenous bone was used in experimental group 3. The animals were sacrificed at 8 weeks after implantation. The parts of tibia containing implant were harvested and radiographs were taken for radiographic examination. The specimens were prepared for histological examination and histomorphometric analysis of implant-bone contact ratios.

Results: 1. All implants showed sufficient osseointegration in the cortical bone radiographically and histologically, but osseointergration in the marrow space was not satisfactory. 2. Histomorphometrically, the implant-bone contact ratios in the bone marrow was sequentially high in the experimental group 3 (autogenous bone + PRP group), group 1(autogenous bone group), group 2 (PRP group), and control group (non-additive). 3. It was verified that there was statistical significance between two experimental groups (group 1 and 3) and the other groups (group 2 and control group). (P<0.005) 4. However, there was no statistical significance between group 3 and group 1, also group 2 and control group respectively.

Conclusion: These results suggest that platelet rich plasma is effective to osseointegration in the implant installation but there is no statistical significance.